Best Venture Capital Firms in San Francisco

Benjamin Debonneville
Founder & CEO
Connect on


San Francisco: the pulsating heart of Silicon Valley, a beacon for tech wizards and ambitious entrepreneurs. When one thinks of venture capital, doesn’t the glittering skyline of this city immediately leap to mind?

Positioned as the globe’s premier hub for innovation, San Francisco has amassed a treasure trove of venture capital firms. These firms don't just throw cash; they offer wisdom, nurturing fledgling startups into giants.

If you're seeking capital, mentorship, or simply want to dive into the world of VCs, there’s no better place to start than here. So, are you ready to explore the best VC firms the Bay Area boasts? Let’s delve in!

15 Best VC Firms in San Francisco

In the vibrant ecosystem of San Francisco's venture capital, several firms rise above the rest, marking their territory with unparalleled success and influence.

Here are our picked 15 of the most formidable VC firms that the Bay Area proudly showcases:

1. Advanced Technology Ventures

Rooted in Menlo Park's tech-laden soil, Advanced Technology Ventures (ATV) has etched its legacy since 1979.

Boasting an impressive portfolio, ATV has injected funds into over 250 startups, transforming groundbreaking ideas into successful ventures.

With a whopping $1.8 billion in capital management, the firm's eyes are set on startups with disruptive technologies across cleantech, healthcare, and IT.

Their investments shine bright, with Actifo's acquisition by Google and Tripwire's sale to Belden as gleaming testimonials.

Founded by the visionary Dr. Thaddeus after his departure from a Rockefeller-affiliated VC, ATV continues to be a beacon for startups in the Bay Area and beyond.

Best Suited Startups:

  • Medical Innovators: With a keen eye on healthcare, ATV is a magnet for startups revolutionizing the medical landscape. A golden chance for trailblazers!
  • Cleantech Pioneers: Pushing the boundaries of sustainable technology? ATV's expertise in cleantech positions them as your ideal ally in combating climate challenges.
  • Emergent IT Visionaries: If you're dabbling in disruptive IT solutions, ATV is the wind beneath your wings. Their legacy in backing robust IT startups is a testament.

2. Benchmark Capital

Birthed in 1995, Benchmark Capital, headquartered in San Francisco, stands as a titan in the VC landscape.

Laser-focused on aiding entrepreneurs, Benchmark has a proven track record, boasting monumental investments like Twitter, WeWork, and Snap Inc.

An astonishing $2.5 billion in funds raised is testimony to their prowess. Their genius? A hands-on approach to every venture, with a no-nonsense, partner-only team.

From their game-changing $6.7 million investment in eBay, which yielded 22.1%, to their $12 million in Uber, now worth a staggering $9.4 billion in 2023 – Benchmark's footprints are all over tech's hall of fame.

Best Suited Startups:

  • Digital Trendsetters: Startups aiming to disrupt the social, mobile, local, and cloud spaces, mirroring Benchmark’s core areas.
  • Transformational Tech Visionaries: Entrepreneurs keen on morphing startups into game-changers in the tech industry.
  • Innovative Software: Young companies pushing the envelope in open-source, AI, enterprise, and infrastructure software, aligning with Benchmark’s passion.

3. Mindset Ventures

Embracing the ethos "invest in boundless minds," Mindset Ventures stands as a beacon for nascent tech talents from the US and Israel.

Grounded in San Francisco, this VC heavyweight marries the zeal of unbounded thinking with strategic investments, focusing chiefly on B2B tech companies.

Whether it's seeding a fledgling idea or driving a series round, they splash investments ranging from $100,000 to $500,000, with notable bets on Priori, Konnecto, and Sizzle.

But it's not just about the money; they fortify their portfolio companies with a panoply of support services, from PR & marketing to international expansion, thereby ensuring these startups not only soar but redefine industries.

Best Suited Startups:

  • Tech Trailblazers: Ventures sculpting the next big wave in the tech space, especially those breaching conventional boundaries.
  • B2B Innovators: Startups tailoring robust business-to-business solutions, aligning with Mindset's keen interest.
  • Global Visionaries: Entrepreneurs eyeing global footprints, especially those looking to make a mark in Latin America.

4. Andreessen Horowitz

Founded by tech veterans Marc Andreessen and Ben Horowitz in 2009, Andreessen Horowitz (a16z) is a powerhouse venture capital firm with a massive $32.4B under management.

Stationed in San Francisco and New York, they've championed over 1256 investments, boasting 191 successful exits.

Their portfolio shines with industry giants like Facebook, Airbnb, and Groupon.

Dedicated to innovative realms from bio-health to crypto, they are not just investors; they're partners, deeply valuing long-term relationships and understanding the essence of entrepreneurial challenges.

Best Suited Startups:

  • Tech-Forward Innovators: Startups pushing boundaries in areas like crypto, fintech, and enterprise solutions find a true advocate in a16z.
  • Disruptive Visionaries: With investments in game-changers like Airbnb and Coinbase, they value those altering industry landscapes.
  • Founder-Centric Models: a16z respects the journey and challenges of founders, making them an ally for entrepreneur-driven ventures.

5. Costanoa Ventures

Costanoa Ventures, based in Palo Alto and San Francisco, champions early-stage startups with a knack for fintech, AI, Web3, and more.

Launched in 2012 by Greg Sands, this California-based VC firm prides itself on backing innovative founders as early as company formation, dedicating between $2 million and $5 million per investment.

With a boutique approach, they support only a select few each year, ensuring extensive resources and hands-on operational expertise for every partner.

Their track record boasts 164 investments, 20 successful exits, and an impressive $890 million in funds raised. Standout investments include Highnote, Noyo, and Coiled.

Best Suited Startups:

  • Early-Stage Technical Innovators: Startups delving deep into fintech, data, and Web3, aiming to reshape apps and infrastructure.
  • Global Visionaries: Companies rooted or focusing on diverse regions like Latin America, Europe, Africa, and Australia, bringing global perspectives.
  • Seed Ventures in Niche Markets: Firms targeting unique and sometimes underappreciated sectors like developer infrastructure, applied AI, and security.

6. Redpoint Ventures

Founded in 1999 by a team of five visionaries, San Francisco-based Redpoint Partners has since emerged as a titan in the VC realm.

They've demonstrated an impressive commitment to both consumer and enterprise startups, from seed to growth stage. Their journey boasts 711 investments, 160 stellar exits, and an eye-popping $4.5 billion in funds raised.

With a financial reach ranging from $100,000 to a whopping $10 million, their portfolio sparkles with gems like Zendesk, Draftkings, and Sonos.

Success stories Twilio, Stripe, and Guild further underscore their knack for picking winners.

Best Suited Startups:

  • Cutting-Edge Tech Pioneers: Entrepreneurs leading in sectors like blockchain, fintech, and healthcare.
  • Consumer-Focused Innovators: Startups aiming to revolutionize the consumer experience, from applications to entertainment platforms.
  • Enterprise Trailblazers: Visionaries intent on reshaping business operations and infrastructure for the modern age.

7. Kleiner Perkins

Born in 1972, Kleiner Perkins sits as a titan among venture capital firms. With its roots deep in San Francisco and Shanghai, it boasts a staggering 1,354 investments and 318 notable exits, amassing an eye-watering $9.2 billion in funds.

Pioneering since the early days of venture capital, their touch has turned startups into legends - think Google, Uber, and Twitter.

Their appetite spans across a vast array of industries, from fintech to healthcare, dishing out checks between $500,000 to a cool $15 million.

With a legacy of five decades, Kleiner Perkins remains the ally for founders eager to etch their names in history.

Best Suited Startups:

  • Tech Visionaries: Startups pioneering in areas like SaaS, cybersecurity, and deep tech.
  • Healthcare Innovators: Enterprises venturing into life sciences, biotech, and cutting-edge medical solutions.
  • Global Disruptors: Bold thinkers in consumer, fintech, and mobile sectors with global ambitions and game-changing ideas.

8. Greylock Partners

Founded in 1965 by Bill Elfers, Greylock Partners stands as an iconic VC firm in San Francisco, with a keen eye on turning ideas into impactful businesses.

With a hefty $4.6 billion in funds, they've made a remarkable 813 investments, celebrating 245 successful exits.

They're not just about the money; they're about the mission - from supporting Airbnb's transformative travel vision to investing in tech giants like Coinbase and Meta.

For Greylock, it’s more than an investment; it's a partnership, guiding startups from their infancy to their industry-changing potential.

Best Suited Startups:

  • Tech Trailblazers: Innovative startups looking to revolutionize the consumer or enterprise software landscape.
  • Crypto Pioneers: Businesses venturing into blockchain or crypto, aiming to redefine financial and transactional norms.
  • Impactful Visionaries: Founders with a transformative idea and unyielding ambition, eager to make a lasting mark.

9. Blumberg Capital

Headquartered in San Francisco, Blumberg Capital is more than a VC firm. Its logo, inspired by Leonardo da Vinci's "Flying Sphere," signifies enduring support through every startup twist and turn.

From a foundation as early investors in 8 unicorns, they've steadfastly backed tech visionaries, injecting 90% of their capital in Seed rounds and reserving 60% for growth stages.

With initial investments ranging from $500k to $5M, Blumberg's global footprint, spanning Miami to Tel Aviv, ensures that founders are primed for global success.

Their impressive portfolio boasts names like Nutanix, Braze, and Fundbox, testifying to their commitment and expertise in nurturing transformative tech solutions.

Best Suited Startups:

  • Tech Visionaries: Innovators harnessing AI and transformative technologies to reshape industries.
  • Global Aspirants: Startups aiming to scale internationally, benefiting from Blumberg's multi-city presence.
  • Deep Collaboration Seekers: Companies valuing hands-on guidance, from recruitment to marketing and operational strategies.

10. Opus Capital

Nestled in Menlo Park, San Francisco Bay Area, Opus Capital shines with over 60 years of hands-on operational experience from iconic firms like AOL and Juniper Networks.

With an impressive $1 billion under management and participation in 50 IPOs, their impact resonates in names like FedEx and DoubleClick.

Their mantra? Invest beyond just capital. They pour in time, energy, expertise, and profound insights, offering a foundation of knowledge and mentorship.

For Opus, the journey doesn't just end at funding; they stand shoulder-to-shoulder with entrepreneurs, propelling them towards robust and lasting growth.

Their undying commitment? Helping tech startups flourish in dynamic landscapes.

Best Suited Startups:

  • Tech Trailblazers: Startups aiming to redefine technology landscapes, echoing giants like FedEx or DoubleClick.
  • Growth Seekers: Early-stage tech ventures hunting for more than capital - seeking mentorship, strategic insights, and sustainable growth pathways.
  • Change Navigators: Companies poised to thrive in dynamic environments, leveraging Opus' wealth of operational expertise.

11. Technology Crossover Ventures (TCV)

Born in 1995, Technology Crossover Ventures (TCV) is a San Francisco heavyweight in the VC realm, boasting a staggering $21 billion in assets.

With a hefty track record of 79 IPOs and 71 M&A exits, TCV's impact is echoed in transformative names like Meta, Netflix, and Spotify.

With a deep-rooted commitment to tech, they've poured over $17 billion into both fledgling and established tech marvels.

Their approach is personal, rooted in core values, and championing excellence. Whether it's a $10 million nudge or a $400 million leap, TCV stands by visionaries, turning pitch decks into global phenomenons.

Best Suited Startups:

  • Tech Titans in the Making: Companies eyeing to redefine sectors like e-commerce, entertainment, or fintech with disruptive innovations.
  • Growth Chasers: Startups in late stage or Series A/B, ready for hefty investments to catapult their market presence.
  • Visionary Ventures: Trailblazing ideas in realms like prop-tech, education, or media, seeking partnerships that transcend mere capital.

12. Spark Capital

Established in 2005, Spark Capital isn't just any VC firm—it's the embodiment of unconventional thinking.

Hailing from San Francisco but stretching to Boston and New York, they've poured $3.8 billion across 507 ventures, from early-birds to mature tech stars.

No playbooks, just gut and instinct. This unique approach led them to home runs like Twitter, Coinbase, and Wayfair. They don’t just throw cash; they offer mentorship and immerse in the journey.

From a modest $500k to a whopping $25 million, their checks have one thing in common: belief in groundbreaking ideas. If you're upending norms, Spark's your partner in crime.

Best Suited Startups:

  • Trailblazing Techies: Startups reshaping tech boundaries—think next Coinbase or Twitter—eager for more than just funds.
  • Early-Bird Innovators: If you're in the seed or Series A stage with a disruptive model, Spark's got your back.
  • Diverse Dreamers: Across consumer, fintech, software, or even the crypto realm—if your idea shatters molds, Spark's interested.

13. Sequoia Capital

Established in 1972, Sequoia Capital is a venture capital titan, extending from San Francisco to Bangalore.

Boasting powerful success stories like Apple, Google, and Nvidia, they've clocked 1712 investments, 350 exits, and hold a hefty $22 billion fund.

Sequoia isn't just about money; they partner with visionaries, often from just an idea. Pioneering the journey from seed to IPO and beyond, they stand as unwavering allies for startups.

Their commitment is long-term, seeing potential when others might not. Their legacy? A trail of transformation in the business world.

Best Suited Startups:

  • Tech Visionaries: Startups revolutionizing technology, from AI and blockchain to internet platforms.
  • Healthcare Innovators: Ventures focusing on groundbreaking healthcare solutions and advancements.
  • Consumer Champions: Startups targeting dynamic shifts in consumer behavior, needs, and aspirations.

14. True Ventures

Founded in 2005 by Jon Callaghan, True Ventures is a San Francisco-based venture capital behemoth with a foothold in Palo Alto.

With a robust $2 billion fund, they've carved a niche with 707 investments, 183 exits, and a check range of $1 million to $3 million. Famed for backing trailblazers like Peloton and Fitbit, they champion extraordinary founders.

More than just funds, they offer enduring partnerships, embedding themselves in an entrepreneur's creative journey.

Their DNA? An unwavering focus on people, a zeal for risks, and a unique alignment with the mission-driven founders they back.

Best Suited Startups:

  • Tech Trailblazers: Innovative ventures pushing tech boundaries, from mobile to cloud.
  • Consumer Connectors: Startups reshaping consumer experience, from food to media.
  • Cybersecurity Custodians: Initiatives committed to evolving digital protection and data safety standards.

15. Insight Venture Partners

For over a quarter-century, Insight Partners has been the jet fuel behind 800+ visionaries, boasting 55+ IPOs and managing a staggering $80 billion.

Rooted in New York but global in reach, with outposts in London, Tel Aviv, and Palo Alto, their software-centric mindset has shaped industries.

A beacon in software investment, their mastery spans spotting patterns to scaling successes.

Whether you're an ambitious startup or a transformative giant, Insight is your 24/7 co-pilot, accelerating visions into realities.

Celebrated by Forbes and Private Equity International, they aren’t just about funds; they’re about fostering futures.

Best Suited Startups:

  • Software Innovators: Pioneering companies pushing the boundaries of software's potential and reshaping industries.
  • Tech Visionaries: Businesses leveraging technology to drive transformative change within their sectors.
  • Global Game-Changers: Startups with a global outlook, ready to expand and scale across diverse markets.

Final Thoughts

San Francisco's vibrant heart beats in sync with the rhythm of innovation, and it's no surprise that it's a magnet for the world's leading venture capital firms. Anchoring themselves in this tech haven, these VC firms aren't just observers; they're the pulse.

With every investment in a budding startup, they reaffirm San Francisco's legacy as a global tech powerhouse. Their commitment ensures that the city remains at the cutting edge, continually redefining the horizon of what's possible.

So, here's to the dreamers, the innovators, and the venture capitalists backing them – together, they craft the future of San Francisco and, by extension, the world.

Benjamin gave great tips to my start-up Blend for polishing and optimising my pitch deck, refreshing perspective. Recommend!